This could be anything from a tooth that needs to be pulled to serious spinal disease. All I can say for sure is that it sounds like he's in tremendous pain. (I say tremendous because dogs are genetically wired to hide their pain.)
Vet ASAP, and meanwhile no stairs, no steps, no jumping. If it is his spine any activity that stresses it could lead to major damage, so better safe than sorry.
Please keep us updated. I sincerely hope it's nothing serious.
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