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Has anyone had any adverse side effects giving Simparica flea and tick to their Mini Poodle. Thanks!
 

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I'd used it for my boys til they were about 6m old with no ill effects. What symptoms are you seeing? When did they start? Do they get worse then better?
 

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My vet recently switched to simpirico and I bought one dose. I chose to consider if I want to continue or switch to something else. After careful consideration, I've chosen not to continue with it even though there's been no side effects from the one dose. The FDA issued a warning for drugs in the isoxazoline class as they may cause neurological symptoms. My fear is neurological symptoms may not be apparent. Humans and dogs can have a seizure with no apparent signs or symptoms.

Here is a link:

For the record, the above is solely my opinion within the context of my own dog.

I would not give advise to use or not to use but leave it up to each owner what is the best thing to do for their dog. The medication is vet approved and dogs have taken it and been absolutely fine. For example, Credelio is in the same aforementioned class of drug and I gave it to my dog for a year with no apparent side effects. Granted I did not do independent research of the potential side effects, like I am now. In summary, all meds have potential side effects.
 

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To clarify, the FDA didn't issue an actual warning, but rather an alert. This is because the drug label hadn't previously included some potential neurological side effects which reports were being made on. The manufacturers are to add these potential side effects on the warning label. I don't know if this has been done yet. The FDA considers the drugs safe but do recommend speaking with your vet about all potential side effects, especially in relation to your pets general health history.

The FDA's role is to collect data from vets, clinics, and owners and issue guidance based on that data.

This is the link to the FDA requesting label information changes by the manufacturers:

This is a link to the FDA's Electronic Reading Room with info on a number of complaints made on various products. The isoxazoline products data is listed toward the bottom under Safety and Health:

This is the link to the collected data for Simparica:

This last link is strictly an example since it's for reports of DCM but this is the way the FDA gathers the data that they then issue statements on.
 
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