I just ordered Kiara's NE test from VetGen, and was wondering if I would also need to get the NEwS test from OFA since they are both tests for the same thing?
I am still wondering that....Could any of you tell us..are the tests at vetgen and OFA testing for the same thing, or does "with seizures" mean they are NOT testing for the same disease???? I want to make sure to do everything I can to ensure when Kiara is ready to have pups that she has been tested as completely as possible.but is the NE test from vetgen, and the NEwS test testing for the same thing??
Here is a link I foundThank you, that is what I needed...but do you know what the "and then some" of the test would be?
I went to Vetgens site and they only offer NE not NEwsVon Willebrand’s disease has been identified in a wide range of canine breeds, and is the most common of the inherited bleeding disorders. As with humans, there are three classifications of this disease, Types I, II, and III. These are based on the concentration and nature of plasma vWF. Type I vWD is characterized by abnormally low concentrations of structurally normal vWF, and tends to be a milder and more variable form. Type II vWD is characterized by structurally abnormal vWF, which impedes function and results in severe bleeding in affected animals. Type III vWD is found in animals that have essentially no plasma vWF. The disease has been reported in many breeds of dog, and is generally diagnosed by an ELISA test for plasma vWF following a bleeding event.
Five mutations have been identified that cause vWD in canines. Direct DNA tests have been developed for all five of these mutations that allow unambiguous delineation of the genetic status of the animal, which is not always possible with the ELISA test due to temporal variations in the amount of circulating vWF. These five mutations are responsible for the vast majority of vWD in at least the fifteen breeds discussed in this poster, and probably others, which have yet to be tested. All five may be classified as recessively inherited resulting in clear, carrier, or affected status. While carriers do exhibit a reduction in the amount of plasma vWF, it is not enough to make them symptomatic. It should be noted that affected status in the case of these tests means the animal carries two copies of the mutant allele, not necessarily that the disease is manifest. In the case of the severe Type II and III diseases any “affected” animal will almost certainly experience a severe bleeding incident. In the case of the milder and more variable Type I disease, “affected” animals are obviously at risk, but may or may not have a severe bleeding incident.
VetGen has now being offering DNA testing for vWD for more than ten years, and has tested over 20,000 dogs.
According to this article - VetGen is more reliable test since markers amount can variate in circulating blood depending of the day sample was taken or how it was taken and so forth ...
Hope this helps you guys