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Discussion Starter #1
I just ordered Kiara's NE test from VetGen, and was wondering if I would also need to get the NEwS test from OFA since they are both tests for the same thing?
 

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I ordered Flynn's vWd and NEWS through a clinic. They mailed me the swabs, and it was way less expensive than doing it any other way. They also informed me the swabs are more reliable. I believe the vetgen test results can be posted on OFA.
 

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Yes...........OFA will post results from VetGen. There is an extra cost but it is minimal. I loved that I received results via e-mail in exactly one week!!!
Tess
 

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If I may say something as a biologist - any sample of any tissue will give more than enough of genetic material for any marker analysis.

HOWEVER - depending of the laboratory technique used to identify the marker and its sophistication and sensitivity the results may wary. If the technique is crude and uses more old fashioned methods, some samples can come as false positive or false negative.

So, it is possible that one method is better than the other , but not in the way sample was taken.
 

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Von Willebrand’s disease has been identified in a wide range of canine breeds, and is the most common of the inherited bleeding disorders. As with humans, there are three classifications of this disease, Types I, II, and III. These are based on the concentration and nature of plasma vWF. Type I vWD is characterized by abnormally low concentrations of structurally normal vWF, and tends to be a milder and more variable form. Type II vWD is characterized by structurally abnormal vWF, which impedes function and results in severe bleeding in affected animals. Type III vWD is found in animals that have essentially no plasma vWF. The disease has been reported in many breeds of dog, and is generally diagnosed by an ELISA test for plasma vWF following a bleeding event.
Five mutations have been identified that cause vWD in canines. Direct DNA tests have been developed for all five of these mutations that allow unambiguous delineation of the genetic status of the animal, which is not always possible with the ELISA test due to temporal variations in the amount of circulating vWF. These five mutations are responsible for the vast majority of vWD in at least the fifteen breeds discussed in this poster, and probably others, which have yet to be tested. All five may be classified as recessively inherited resulting in clear, carrier, or affected status. While carriers do exhibit a reduction in the amount of plasma vWF, it is not enough to make them symptomatic. It should be noted that affected status in the case of these tests means the animal carries two copies of the mutant allele, not necessarily that the disease is manifest. In the case of the severe Type II and III diseases any “affected” animal will almost certainly experience a severe bleeding incident. In the case of the milder and more variable Type I disease, “affected” animals are obviously at risk, but may or may not have a severe bleeding incident.
VetGen has now being offering DNA testing for vWD for more than ten years, and has tested over 20,000 dogs.
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According to this article - VetGen is more reliable test since markers amount can variate in circulating blood depending of the day sample was taken or how it was taken and so forth ...

Hope this helps you guys :)
 

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Thanks for that wishpoo Man I paid through the wazoo for the whole blood so I am very happy to say that the cheek swab is good and effective Now I dont have to make the 5 hour drive one way WAHOO..... Vetgen eh?
 

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Discussion Starter #11
but is the NE test from vetgen, and the NEwS test testing for the same thing??
I am still wondering that....Could any of you tell us..are the tests at vetgen and OFA testing for the same thing, or does "with seizures" mean they are NOT testing for the same disease???? I want to make sure to do everything I can to ensure when Kiara is ready to have pups that she has been tested as completely as possible.

Thank you for the great info WishPoo! But, you spoke of vWD and that is great, but what about the NE and NEwS tests?
 

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Von Willebrand’s disease has been identified in a wide range of canine breeds, and is the most common of the inherited bleeding disorders. As with humans, there are three classifications of this disease, Types I, II, and III. These are based on the concentration and nature of plasma vWF. Type I vWD is characterized by abnormally low concentrations of structurally normal vWF, and tends to be a milder and more variable form. Type II vWD is characterized by structurally abnormal vWF, which impedes function and results in severe bleeding in affected animals. Type III vWD is found in animals that have essentially no plasma vWF. The disease has been reported in many breeds of dog, and is generally diagnosed by an ELISA test for plasma vWF following a bleeding event.
Five mutations have been identified that cause vWD in canines. Direct DNA tests have been developed for all five of these mutations that allow unambiguous delineation of the genetic status of the animal, which is not always possible with the ELISA test due to temporal variations in the amount of circulating vWF. These five mutations are responsible for the vast majority of vWD in at least the fifteen breeds discussed in this poster, and probably others, which have yet to be tested. All five may be classified as recessively inherited resulting in clear, carrier, or affected status. While carriers do exhibit a reduction in the amount of plasma vWF, it is not enough to make them symptomatic. It should be noted that affected status in the case of these tests means the animal carries two copies of the mutant allele, not necessarily that the disease is manifest. In the case of the severe Type II and III diseases any “affected” animal will almost certainly experience a severe bleeding incident. In the case of the milder and more variable Type I disease, “affected” animals are obviously at risk, but may or may not have a severe bleeding incident.
VetGen has now being offering DNA testing for vWD for more than ten years, and has tested over 20,000 dogs.
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According to this article - VetGen is more reliable test since markers amount can variate in circulating blood depending of the day sample was taken or how it was taken and so forth ...

Hope this helps you guys :)
I went to Vetgens site and they only offer NE not NEws
 

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It is only 7.50 extra for Vetgen to post your results on OFA. Vetgen is also faster than OFA. You can get your results by email within a week or two. It will take about a month or longer to get your OFA certificate. Vetgen doesn't test for D.M. though so you would have to go with OFA.
 

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Discussion Starter #19
Thank you to all of you, I was looking for the answer to this and realized I have OFA on my facebook, so I went to them and asked and this was what they said.



Orthopedic Foundation for Animals
Orthopedic Foundation for Animals
The test was actually developed at the University of Missouri and offered through the OFA, but the OFA did not patent the test. The test VetGen offers is the same test. The difference is that with VetGen you will need to pay a separate submission fee to the OFA if you want the results on your OFA record, and if you test through the OFA it's automatically recorded. --Robin
29 minutes ago · Report

Since I already purchased the test through VetGen and wanted to really be sure I did not need to have both tests done, they cleared it up for me. I will be getting other tests through them if I can..to bad they don't offer the vWD test.
 

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Wow that is good to know that I can belong on Facebook . Got a new puter in the works so once it gets here I will look into this.. The university of missouri is where the blood test went..Awesome that it is now a cheek swab ! Thanks you so much for posting this today !
 
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