I would definitely ask your vet's opinion on that. My sister has given her 5 lb. Chihuahua Heartgard Plus with no problems. On the label it says "For dogs up to 25 lbs." so I presume it would be safe for all dogs, but I'd double check to be safe.
Just went to the vet today and got TriHeart Plus for dogs under 25 pounds. Miracle is 12 pounds and Jasper is around 8-9 pounds. Both will be on it. I have never had a problem with any of these medicines for smaller dogs.
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