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I think for a first litter the dog should be between 3 and 5 years old as like it was mentioned hips needs to be scored and eyes need to be clear and most signs of PRA show up between 4 & 6 years of age.
As for when to stop breeding I think no bitch should be bred after 8yo, for a dog 10yo.
As for when to stop breeding I think no bitch should be bred after 8yo, for a dog 10yo.